- c. 450: St. Patrick missionary journey to Ireland.
- 496: Clovis, king of the Franks, converts to Catholic Christianity.
- 529: St. Benedict establishes the Benedictine rule for the monastery at Monte Cassino
- 565-750: Christianization of Britain
- c. 587: The Visigoths convert to Catholic Christianity.
- 590-604: Pope Gregory the Great
- c. 722-754: St. Boniface's missionary work in eastern Germany.
- 768-814: Reign of Charlemagne
- 1075-1122: The Investiture Controversy
- 1095-1291: The Crusading Era
- 1181 or 1182-1226: Saint Francis of Assisi
- 1225-1274: St. Thomas Aquinas
- 1305-1377: Babylonian Captivity of the Papacy
- 1378-1415: The Great Schism
- 1382: John Wyclif's teachings are condemned by the Synod of London.
- 1414: Thomas a Kempis, "The Imitation of Christ."
- 1415: Jan Hus is burned as a heretic.
- 1494: Savanarola's theocratic government in Florence.
- 1501: Erasmus of Rotterdam, "Enchiridian militis christiani" [Handbook of the Militant Christian].
- 1500-1598: The Protestant Reformation
- 1500-1565: The Catholic Reformation
- 1500-1650: The Wars of Religion
- 1598: The Edict of Nantes
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